The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-kB positive feedback loop in peripheral T-cell lymphoma
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چکیده
The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-kB positive feedback loop in peripheral T-cell lymphoma Rebecca L. Boddicker, N. Sertac Kip, Xiaoming Xing, Yu Zeng, Zhi-Zhang Yang, Jeong-Heon Lee, Luciana L. Almada, Sherine F. Elsawa, Ryan A. Knudson, Mark E. Law, Rhett P. Ketterling, Julie M. Cunningham, Yanhong Wu, Matthew J. Maurer, Megan M. O’Byrne, James R. Cerhan, Susan L. Slager, Brian K. Link, Julie C. Porcher, Deanna M. Grote, Diane F. Jelinek, Ahmet Dogan, Stephen M. Ansell, Martin E. Fernandez-Zapico, and Andrew L. Feldman
منابع مشابه
The oncogenic transcription factor IRF4 is regulated by a novel CD30/NF-κB positive feedback loop in peripheral T-cell lymphoma.
Peripheral T-cell lymphomas (PTCLs) are generally aggressive non-Hodgkin lymphomas with poor overall survival rates following standard therapy. One-third of PTCLs express interferon regulatory factor-4 (IRF4), a tightly regulated transcription factor involved in lymphocyte growth and differentiation. IRF4 drives tumor growth in several lymphoid malignancies and has been proposed as a candidate ...
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تاریخ انتشار 2015